AKT1 and genetic vulnerability to bipolar disorder

Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?

Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation. We conducted a meta-analysis of all published ...

Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder.

There is substantial evidence for partial overlap of genetic influences on schizophrenia and bipolar disorder, with family, twin, and adoption studies showing a genetic correlation between the disorders of around 0.6. Results of genome-wide association studies are consistent with commonly occurring genetic risk variants, contributing to both the shared and nonshared aspects, while studies of la...

Genetic Association Studies of Bipolar Disorder

Bipolar disorder is a common and serious mental illness. The occurrence o f mania is central to the diagnosis, but affected individuals typically also suffer episodes of depression. The results o f family, twin and adoption studies argue convincingly for genetic susceptibility to bipolar disorder. Linkage studies conducted at the Molecular Psychiatry Laboratory, UCL have previously implicated t...

Running
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 Polarized Perspectives: Environmental and Genetic Causes of Bipolar Disorder

Risk and resilience in bipolar disorder: rationale and design of the Vulnerability to Bipolar Disorders Study (VIBES).

BD (bipolar disorder) is among the ten most significant causes of disability worldwide. Neuroscientists and clinicians have yet to meet the challenge of reducing this disability burden. The main obstacle to date has been our incomplete understanding of the pathophysiology of BD which thwarts primary prevention and early diagnosis and hinders effective treatment. There is a need to move beyond d...